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CAS 224785-90-4
Langyou
224785-90-4
224785-90-4
Basic Info:
Product: Vardenafil
CAS: 224785-90-4
Form: White Crystalline Powder
Purity: 99%
MF: C23H32N6O4S
MW: 488.6
Package: 1-2kg/Aluminum Foil Bag, 25kg/Drum Factory supply
Sample: Available (Freight need to be paid）
Production Capacity: 200kg/Month
Payment Terms: 100% T/T, Western Union, Money Gram, Bitcoin, Tether, Monero, Bank Transfer
Delivery Time: Ship out immediately once receiving Payment
Note: Guarantee Customs
Synonyms: VARDENAFIL(SUBJECTTOPATENTFREE);VARDENAFILHYDROCHLORIDETRIHYDRATE(SUBJECTTOPATENTFREE);2-(2-Ethoxy-5-(4-ethylpiperazin-1-yl-1-sulfonyl)phenyl)-5-methyl-7-propyl-3H-imidazo(5,1-f)(1,2,4)triazin-4-one;Vardenafilhydrochloridetrihydrate99%;VardenafilHydrochlorideTrihydraChemicalbookteCas#224785-90-4ForSale;ManufacturersSupplybestqualityVardenafilhydrochloridetrihydrate224785-90-4CASNO.224785-90-4;FADINAF;1-[[3-(1,4-Dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethyl-piperazinehydrochloridetrihydrate
Description:
Vardenafil is metabolised in the liver primarily by cytochrome P450 isoenzymes CYP3A4 (the major route) as well as CYP3A5 and CYP2C isoforms. The major metabolite produced by desethylation of vardenafil also has some activity.
Vardenafil is excreted as metabolites mainly in the faeces (91 to 95
%), and to a lesser extent in the urine.
Vardenafil is a new PDE5 inhibitor launched for oral treatment of male erectile dysfunction and it has significant structural similarity with sildenafil (Viagra?), which was the first PDE5 inhibitor introduced in 1998 for this indication. Vardenafil is synthesized in three steps starting with a cyclization reaction of 2-ethyoxybenzamidine with 2-butyramidopropionic acid and ethoxyallyl chloride to construct the imidazotriazine ring system, followed by sulfonation to the corresponding sulfonyl chloride and subsequent condensation with 1-ethylpiperazine. The potency of PDE5 inhibition by vardenafil (IC50=0.7 nM) is ～10 times greater than that of sildenafil (IC50=6.6 nM). Vardenafil is typically administered in single doses of 10 and 20 mg. The time to reach maximum plasma concentration is 0.75 h, which is slightly shorter than those of sildenafil (tmax=1.16 h) and tadalafil (tmax=2h), and the half-life is 4–5 h. Although it is almost completely absorbed following oral administration, the mean absolute bioavailability of a 10 mg dose is ～15%, resulting from extensive first pass metabolism. Vardenafil is metabolized in the liver primarily by CYP3A4 and is eliminated mainly in feces. In clinical studies, 10–20 mg doses of vardenafil was well tolerated and efficacious in patients with ED of various severities, including subjects with comorbidities such as diabetes mellitus or hypertension or hyperlipidemia. The side-effect profile of vardenafil is similar to that of sildenafil, with headache, flushing, dyspepsia and nasal congestion being the most common adverse events. Vardenafil has systemic vasodilatory properties, which can cause transient decrease in supine blood pressure; however, it does not appear to translate into clinical effects. The mean maximum decreases in supine systolic blood pressure following 20 and 40 mg vardenafil were 6.9 and 4.3 mmHg, respectively, when compared to placebo. However, single and multiple oral doses of vardenafil up to 40 mg produced no clinically relevant changes in the ECGs of normal male volunteers.
Advantage:
Hubei Langyou International Trading Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high-quality products at competitive prices in quick delivery with 100% CUSTOMS PASS GUARANTEED. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, the USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay, and many other countries.
1. Quality: Every batch of our products has to be tested by our QC(quality control) before they are allowed to sell.
2. Delivery: Stock is available, so we can deliver quickly on the very day when receiving the payment. Within 24 hours after receiving the payment and Lead time is 4 or 7 days.
3. Package: Safely and Professionally Disguised Package Guaranteed. For your safety and to insure delivery, all products will be packed in a discreet way to prevent any suspicions, no products-related name will appear on the parcels and have high successful delivery rate
4. Warm After-Sale Service: Any questions, feel free to contact us at any time, we will make a prompt response as soon as possible.
Best Seller Products:
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Contact Info:
Email: niyoe@protonchem.cn
WhatsApp/Telegram: 86-17720330692
Threema ID: DA4UTK6D
Basic Info:
Product: Vardenafil
CAS: 224785-90-4
Form: White Crystalline Powder
Purity: 99%
MF: C23H32N6O4S
MW: 488.6
Package: 1-2kg/Aluminum Foil Bag, 25kg/Drum Factory supply
Sample: Available (Freight need to be paid）
Production Capacity: 200kg/Month
Payment Terms: 100% T/T, Western Union, Money Gram, Bitcoin, Tether, Monero, Bank Transfer
Delivery Time: Ship out immediately once receiving Payment
Note: Guarantee Customs
Synonyms: VARDENAFIL(SUBJECTTOPATENTFREE);VARDENAFILHYDROCHLORIDETRIHYDRATE(SUBJECTTOPATENTFREE);2-(2-Ethoxy-5-(4-ethylpiperazin-1-yl-1-sulfonyl)phenyl)-5-methyl-7-propyl-3H-imidazo(5,1-f)(1,2,4)triazin-4-one;Vardenafilhydrochloridetrihydrate99%;VardenafilHydrochlorideTrihydraChemicalbookteCas#224785-90-4ForSale;ManufacturersSupplybestqualityVardenafilhydrochloridetrihydrate224785-90-4CASNO.224785-90-4;FADINAF;1-[[3-(1,4-Dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethyl-piperazinehydrochloridetrihydrate
Description:
Vardenafil is metabolised in the liver primarily by cytochrome P450 isoenzymes CYP3A4 (the major route) as well as CYP3A5 and CYP2C isoforms. The major metabolite produced by desethylation of vardenafil also has some activity.
Vardenafil is excreted as metabolites mainly in the faeces (91 to 95
%), and to a lesser extent in the urine.
Vardenafil is a new PDE5 inhibitor launched for oral treatment of male erectile dysfunction and it has significant structural similarity with sildenafil (Viagra?), which was the first PDE5 inhibitor introduced in 1998 for this indication. Vardenafil is synthesized in three steps starting with a cyclization reaction of 2-ethyoxybenzamidine with 2-butyramidopropionic acid and ethoxyallyl chloride to construct the imidazotriazine ring system, followed by sulfonation to the corresponding sulfonyl chloride and subsequent condensation with 1-ethylpiperazine. The potency of PDE5 inhibition by vardenafil (IC50=0.7 nM) is ～10 times greater than that of sildenafil (IC50=6.6 nM). Vardenafil is typically administered in single doses of 10 and 20 mg. The time to reach maximum plasma concentration is 0.75 h, which is slightly shorter than those of sildenafil (tmax=1.16 h) and tadalafil (tmax=2h), and the half-life is 4–5 h. Although it is almost completely absorbed following oral administration, the mean absolute bioavailability of a 10 mg dose is ～15%, resulting from extensive first pass metabolism. Vardenafil is metabolized in the liver primarily by CYP3A4 and is eliminated mainly in feces. In clinical studies, 10–20 mg doses of vardenafil was well tolerated and efficacious in patients with ED of various severities, including subjects with comorbidities such as diabetes mellitus or hypertension or hyperlipidemia. The side-effect profile of vardenafil is similar to that of sildenafil, with headache, flushing, dyspepsia and nasal congestion being the most common adverse events. Vardenafil has systemic vasodilatory properties, which can cause transient decrease in supine blood pressure; however, it does not appear to translate into clinical effects. The mean maximum decreases in supine systolic blood pressure following 20 and 40 mg vardenafil were 6.9 and 4.3 mmHg, respectively, when compared to placebo. However, single and multiple oral doses of vardenafil up to 40 mg produced no clinically relevant changes in the ECGs of normal male volunteers.
Advantage:
Hubei Langyou International Trading Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high-quality products at competitive prices in quick delivery with 100% CUSTOMS PASS GUARANTEED. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, the USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay, and many other countries.
1. Quality: Every batch of our products has to be tested by our QC(quality control) before they are allowed to sell.
2. Delivery: Stock is available, so we can deliver quickly on the very day when receiving the payment. Within 24 hours after receiving the payment and Lead time is 4 or 7 days.
3. Package: Safely and Professionally Disguised Package Guaranteed. For your safety and to insure delivery, all products will be packed in a discreet way to prevent any suspicions, no products-related name will appear on the parcels and have high successful delivery rate
4. Warm After-Sale Service: Any questions, feel free to contact us at any time, we will make a prompt response as soon as possible.
Best Seller Products:
CAS 30123-17-2 Tianeptine Sodium Salt
CAS 66981-73-5 Tianeptine
CAS 90212-80-9 CRL-40,941
CAS 110-63-4 1,4-Butanediol/BDO
CAS 385769-84-6 Amino Tadalafil
CAS 171596-29-5 Tadalafil
CAS 330784-47-9 Avanafil
CAS 224785-90-4 Vardenafil
CAS 68497-62-1 Pramiracetam
CAS 110958-19-5 Fasoracetam
CAS 72432-10-1 Aniracetam
CAS 77191-36-7 Nefiracetam
CAS 135463-81-9 Coluracetam
CAS 62613-82-5 Oxiracetam
CAS 77472-71-0 Phenylpiracetam Hydrazide
CAS 314728-85-3 Sunifiram
CAS 56786-63-1 5-alpha-Hydroxy- Laxogenin
CAS 7791-07-3 Sodium Perchlorate Monohydrate
CAS 1890208-58-8 Compound 7P
CAS 138112-76-2 Agomelatine
CAS 10102-18-8 Sodium Selenite
CAS 862189-95-5 Linezolid
CAS 38183-03-8 7,8-Dihydroxyflavone
CAS 1143-70-0 Urolithin A
CAS 55237-19-1 4F-Phenibut
CAS 334-50-9 Spermidine trihydrochloride
CAS 124-20-9 Spermidine
CAS 67881-98-5 2-methacryloyloxyethyl phosphorylcholine (MPC)
CAS 784-38-3 2-Amino-5-chloro-2'-fluorobenzophenone
CAS 1224690-84-9 Tianeptine hemisulfate monohydrate (THM)
Contact Info:
Email: niyoe@protonchem.cn
WhatsApp/Telegram: 86-17720330692
Threema ID: DA4UTK6D
