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CAS 330784-47-9
Langyou
330784-47-9
330784-47-9
Basic Info:
Product: Avanafil
CAS: 330784-47-9
Form: White Crystalline Powder
Purity: 99%
MF: C23H26ClN7O3
MW: 483.95
Package: 1-2kg/Aluminum Foil Bag, 25kg/Drum Factory supply
Sample: Available (Freight need to be paid）
Production Capacity: 200kg/Month
Payment Terms: 100% T/T, Western Union, Money Gram, Bitcoin, Tether, Monero, Bank Transfer
Delivery Time: Ship out immediately once receiving Payment
Note: Guarantee Customs
Synonyms: 4-[[(3-Chloro-4-Methoxyphenyl)Methyl]aMino]-2-[(2S)-2-(hydroxyMethyl)-1-pyrrolidinyl]-N-(2-pyriMidinylMethyl)-5-pyriMidinecarboxaMide;4-((3-chloro-4-Methoxybenzyl)aMino)-2-(2-(hydroxyMethyl)pyrrolidin-1-yl)-N-(pyriMidin-2-ylMethyl)pyriMidine-5-carboxaMide;AvanafilPDE5inhibitor;vanafil;(S)-4-((3-Chloro-4-Methoxybenzyl)aMChemicalbookino)-2-(2-(hydroxyMethyl)pyrrolidin-1-yl)-N-(pyriMidin-2-ylMethyl)pyriMidine-5-carboxaMide;Avanafil4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide;avanfil;(S)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-yl.
Description:
Avanafil (Zepeed) was approved by the Korean Health Ministry for the treatment of erectile dysfunction (ED) in August 2011. Avanafil is a highly selective type 5 phosphodiesterase (PDE5) inhibitor. Avanafil is reported to be the most selective PDE5 inhibitor on the market. The onset of Tmax and half-life also varies among the marketed PDE5 inhibitors. Sildenafil has a Tmax at 1 h and a half-life of 3–5 h. Vardenafil is somewhat similar with a Tmax of 0.6 h and a half-life of 4–6 h. Tadalafil has the longest half-life among the marketed drugs with a half-life of 17 h. Avanafil has a fast onset of action reaching Tmax in 0.6 h with a half-life of 1.2 h. A synthesis of avanafil (TA-1790) is described in the patent literature. The main elimination route of avanafil is through the bile and feces. Avanafil was also found to be reabsorbed through enterohepatic recirculation.
Avanafil was originally discovered at Tanabe Seiyaku (now Mitsubishi Tanabe). JW Pharmaceutical (previously Choongwae Pharma) and VIVUS have since developed and launched avanafil, which is an oral PDE5 inhibitor for the treatment of erectile dysfunction (ED). Although many marketed PDE5 inhibitors (e.g. sildenafil, vardenafil and tadalafil) are available for the treatment of ED, many patients are still unable to achieve the desired results and experience undesired side-effects with these existing medications. As such, second-generation PDE5 inhibitors with enhanced PDE5 selectivity, shorter systemic half-lives, and improved tolerability are desired. Developed to meet these criteria, Avanafil exhibited good oral bioavailability and PDE5 selectivity in both preclinical studies and clinical trials. Avanafil had a short onset of action (35 min) and short half-life (1.5 h).
Avanafil is metabolised in the liver mainly by the cytochrome P450 isoenzyme CYP3A4 and to a minor extent by the CYP2C isoform. Two major metabolites are produced, one of which is active. Avanafil is excreted as metabolites mainly in the faeces (approximately 63%) in the urine (approximately 21%).
Advantage:
Hubei Langyou International Trading Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high-quality products at competitive prices in quick delivery with 100% CUSTOMS PASS GUARANTEED. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, the USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay, and many other countries.
1. Quality: Every batch of our products has to be tested by our QC(quality control) before they are allowed to sell.
2. Delivery: Stock is available, so we can deliver quickly on the very day when receiving the payment. Within 24 hours after receiving the payment and Lead time is 4 or 7 days.
3. Package: Safely and Professionally Disguised Package Guaranteed. For your safety and to insure delivery, all products will be packed in a discreet way to prevent any suspicions, no products-related name will appear on the parcels and have high successful delivery rate
4. Warm After-Sale Service: Any questions, feel free to contact us at any time, we will make a prompt response as soon as possible.
Best Seller Products:
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CAS 171596-29-5 Tadalafil
CAS 330784-47-9 Avanafil
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CAS 1224690-84-9 Tianeptine hemisulfate monohydrate (THM)
Contact Info:
Email: niyoe@protonchem.cn
WhatsApp/Telegram: 86-17720330692
Threema ID: DA4UTK6D
Basic Info:
Product: Avanafil
CAS: 330784-47-9
Form: White Crystalline Powder
Purity: 99%
MF: C23H26ClN7O3
MW: 483.95
Package: 1-2kg/Aluminum Foil Bag, 25kg/Drum Factory supply
Sample: Available (Freight need to be paid）
Production Capacity: 200kg/Month
Payment Terms: 100% T/T, Western Union, Money Gram, Bitcoin, Tether, Monero, Bank Transfer
Delivery Time: Ship out immediately once receiving Payment
Note: Guarantee Customs
Synonyms: 4-[[(3-Chloro-4-Methoxyphenyl)Methyl]aMino]-2-[(2S)-2-(hydroxyMethyl)-1-pyrrolidinyl]-N-(2-pyriMidinylMethyl)-5-pyriMidinecarboxaMide;4-((3-chloro-4-Methoxybenzyl)aMino)-2-(2-(hydroxyMethyl)pyrrolidin-1-yl)-N-(pyriMidin-2-ylMethyl)pyriMidine-5-carboxaMide;AvanafilPDE5inhibitor;vanafil;(S)-4-((3-Chloro-4-Methoxybenzyl)aMChemicalbookino)-2-(2-(hydroxyMethyl)pyrrolidin-1-yl)-N-(pyriMidin-2-ylMethyl)pyriMidine-5-carboxaMide;Avanafil4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide;avanfil;(S)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-yl.
Description:
Avanafil (Zepeed) was approved by the Korean Health Ministry for the treatment of erectile dysfunction (ED) in August 2011. Avanafil is a highly selective type 5 phosphodiesterase (PDE5) inhibitor. Avanafil is reported to be the most selective PDE5 inhibitor on the market. The onset of Tmax and half-life also varies among the marketed PDE5 inhibitors. Sildenafil has a Tmax at 1 h and a half-life of 3–5 h. Vardenafil is somewhat similar with a Tmax of 0.6 h and a half-life of 4–6 h. Tadalafil has the longest half-life among the marketed drugs with a half-life of 17 h. Avanafil has a fast onset of action reaching Tmax in 0.6 h with a half-life of 1.2 h. A synthesis of avanafil (TA-1790) is described in the patent literature. The main elimination route of avanafil is through the bile and feces. Avanafil was also found to be reabsorbed through enterohepatic recirculation.
Avanafil was originally discovered at Tanabe Seiyaku (now Mitsubishi Tanabe). JW Pharmaceutical (previously Choongwae Pharma) and VIVUS have since developed and launched avanafil, which is an oral PDE5 inhibitor for the treatment of erectile dysfunction (ED). Although many marketed PDE5 inhibitors (e.g. sildenafil, vardenafil and tadalafil) are available for the treatment of ED, many patients are still unable to achieve the desired results and experience undesired side-effects with these existing medications. As such, second-generation PDE5 inhibitors with enhanced PDE5 selectivity, shorter systemic half-lives, and improved tolerability are desired. Developed to meet these criteria, Avanafil exhibited good oral bioavailability and PDE5 selectivity in both preclinical studies and clinical trials. Avanafil had a short onset of action (35 min) and short half-life (1.5 h).
Avanafil is metabolised in the liver mainly by the cytochrome P450 isoenzyme CYP3A4 and to a minor extent by the CYP2C isoform. Two major metabolites are produced, one of which is active. Avanafil is excreted as metabolites mainly in the faeces (approximately 63%) in the urine (approximately 21%).
Advantage:
Hubei Langyou International Trading Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high-quality products at competitive prices in quick delivery with 100% CUSTOMS PASS GUARANTEED. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, the USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay, and many other countries.
1. Quality: Every batch of our products has to be tested by our QC(quality control) before they are allowed to sell.
2. Delivery: Stock is available, so we can deliver quickly on the very day when receiving the payment. Within 24 hours after receiving the payment and Lead time is 4 or 7 days.
3. Package: Safely and Professionally Disguised Package Guaranteed. For your safety and to insure delivery, all products will be packed in a discreet way to prevent any suspicions, no products-related name will appear on the parcels and have high successful delivery rate
4. Warm After-Sale Service: Any questions, feel free to contact us at any time, we will make a prompt response as soon as possible.
Best Seller Products:
CAS 30123-17-2 Tianeptine Sodium Salt
CAS 66981-73-5 Tianeptine
CAS 90212-80-9 CRL-40,941
CAS 110-63-4 1,4-Butanediol/BDO
CAS 385769-84-6 Amino Tadalafil
CAS 171596-29-5 Tadalafil
CAS 330784-47-9 Avanafil
CAS 224785-90-4 Vardenafil
CAS 68497-62-1 Pramiracetam
CAS 110958-19-5 Fasoracetam
CAS 72432-10-1 Aniracetam
CAS 77191-36-7 Nefiracetam
CAS 135463-81-9 Coluracetam
CAS 62613-82-5 Oxiracetam
CAS 77472-71-0 Phenylpiracetam Hydrazide
CAS 314728-85-3 Sunifiram
CAS 56786-63-1 5-alpha-Hydroxy- Laxogenin
CAS 7791-07-3 Sodium Perchlorate Monohydrate
CAS 1890208-58-8 Compound 7P
CAS 138112-76-2 Agomelatine
CAS 10102-18-8 Sodium Selenite
CAS 862189-95-5 Linezolid
CAS 38183-03-8 7,8-Dihydroxyflavone
CAS 1143-70-0 Urolithin A
CAS 55237-19-1 4F-Phenibut
CAS 334-50-9 Spermidine trihydrochloride
CAS 124-20-9 Spermidine
CAS 67881-98-5 2-methacryloyloxyethyl phosphorylcholine (MPC)
CAS 784-38-3 2-Amino-5-chloro-2'-fluorobenzophenone
CAS 1224690-84-9 Tianeptine hemisulfate monohydrate (THM)
Contact Info:
Email: niyoe@protonchem.cn
WhatsApp/Telegram: 86-17720330692
Threema ID: DA4UTK6D
